Publicly available RNA-sequencing files were obtained from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database. Using a computational workflow, Automated Reproducible MOdular Workflow for Preprocessing and Differential Analysis of RNA-seq Data (ARMOR), we identified differentially expressed genes in TNBC cells. Discovery of new drugs would enable better treatment of TNBC and could greatly improve patient survival. The poor prognosis and low success rate of surgical treatment and chemotherapy underline the necessity of new treatment options. Additionally, it has heightened risk for metastasis after neoadjuvant chemotherapy (defined as chemotherapy followed by surgical extraction of the tumor) compared to non-TNBC (Liedtke 2014) and the post-surgical recurrence rate of TNBC is as much as 25% (Yin 2020). 40% of TNBC patients will die within five years of diagnosis (Yin 2020). Triple Negative Breast Cancer (TNBC) lacks three typical surface markers of breast cancer-estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2)-which are common targets for endocrine or drug therapy, severely limiting TNBC treatment options. This is a preliminary idea within our interdisciplinary group of a mechanical engineer, biomedical science, and computer science background.įaculty Mentor: Brett Pickett, Brigham Young Universityīreast cancer is the most common tumor type in men and women combined this year the National Cancer Institute estimates there will be 290,560 new cases in the United States and 43,780 deaths (2022). Having access to the right equipment or supplements to help the healing process advance would be very beneficial as well. Advances in technology can bring the physical therapists and the patients closer together with the ability to click on an assigned exercise and learn how it needs to be done with a video or recording would be a game changer for a lot of recovering patients. Each part of this product will give patients the necessary aids to achieve their long-term physical therapy goals. We plan to develop a method to increase the number of patients reaching a positive result with their physical therapy through modern technologies a smart at home physical therapy product that is paired with an app along with a box of equipment and supplements specific to the needs of the patient’s area of focus. New and improved remote and virtual meeting technologies have the potential to make physical therapy more convenient and accessible. This led to patients not knowing what they should be doing to get better or even maintain their progress without the correct equipment. Due to the recent global pandemic, many physical therapy patients were unable to attend appointments and the communication between physical therapists and patients was negatively impacted. The majority of physical therapy patients do not achieve their desired outcomes. Change of Motion: The Revolutionary Shoulder Braceįaculty Mentor: Vinodh Chellamuthu, Utah Tech University
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